Fig. 7: STUB1 suppressed PTX-resistant OC in vivo by regulating HOXB3/PARK7 axis. | Communications Biology

Fig. 7: STUB1 suppressed PTX-resistant OC in vivo by regulating HOXB3/PARK7 axis.

From: STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression

Fig. 7: STUB1 suppressed PTX-resistant OC in vivo by regulating HOXB3/PARK7 axis.

SKOV3/R cells with oe-STUB1 or sh-PARK7 transfection were subcutaneously injected into mice in the presence of PTX. a The images of tumors. b Tumor sizes. c Tumor weight. d Survival rate analysis. e STUB1 and PARK7 levels were determined using a western blot. f GPX4 and PARK7 expression was evaluated by IHC. N = 6. *P < 0.05; **P < 0.01, ***P < 0.001.

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