Fig. 5: Overall mechanism of LPA1 activation by various agonists. | Communications Biology

Fig. 5: Overall mechanism of LPA1 activation by various agonists.

From: Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists

Fig. 5

a–d Schematic representations of the recognition and activation of each LPA1 agonist, highlighting the crucial residues and interactions involved. The thickness of the dashed lines and arrows represents the strength and importance of the interactions. Residues marked with squares are responsible for holding the agonist, while those marked with ovals transmit the binding signal of the compound into the cell.

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