Fig. 3: KLF9 knockdown relieved cartilage injury in OA rats. | Communications Biology

Fig. 3: KLF9 knockdown relieved cartilage injury in OA rats.

From: KLF9-GRK5-HDAC6 axis aggravates osteoarthritis pathogenesis by promoting chondrocyte extracellular matrix degradation and apoptosis

Fig. 3: KLF9 knockdown relieved cartilage injury in OA rats.

The OA model was established by MMTL method, and KLF9 knockdown adenovirus was injected into the joint cavity of rats. A The infection efficiency of KLF9 was measured using real-time PCR and immunohistochemical staining (400×, scale bar: 50 µm; 800×, scale bar: 25 µm). B–D MicroCT, safranin O-fast green staining, OARSI score, and H&E staining were used to analyze the pathological changes of knee tissues (200×, scale bar: 100 µm). $, p < 0.05; $$$, p < 0.001; $$$$, p < 0.0001. n = 6.

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