Fig. 6: Vinorelbine resistance was reversed via the combined inhibition of the TGF-β pathway in mice. | Communications Biology

Fig. 6: Vinorelbine resistance was reversed via the combined inhibition of the TGF-β pathway in mice.

From: Selective inhibition of TGF-β-induced epithelial-mesenchymal transition overcomes chemotherapy resistance in high-risk lung squamous cell carcinoma

Fig. 6

A NCI-H520, HCC15, and NCI-H226 cells were subcutaneously injected into NOD-SCID mice. Once the average tumour volume reached 100 mm³, the mice were randomized to receive different treatments. At 21 days postimplantation, the tumours were collected and weighed (n = 5 mice per group). B Mice were euthanized at 21 days after implantation, and all of the collected tumours are displayed in the figure (n = 5 mice per group). C Tumour volumes of NCI-H520-, HCC15-, and NCI-H226-derived tumours were measured every three days following implantation. Curve plots were generated to illustrate tumour growth associated with different cell line-derived tumours (n = 5 mice per group; ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001, ANOVA). D Tumour volumes of NCI-H520, HCC15, and NCI-H226-derived tumours on day 21 postimplantation were measured before the mice were euthanized (n = 5 mice per group; ns, no significance; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001, t test). E Tumour weights of NCI-H520, HCC15, and NCI-H226-derived tumours were measured after they were harvested from the mice (n = 5 mice per group; ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001, t test).

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