Fig. 2: Profiles of genome-wide somatic alterations in treatment-sensitive and treatment-resistant recurrent breast tumours.

The alteration profiles include, A genome-wide somatic mutational rate, B non-silent somatic mutational burden, C burdens of different types of structural variations (large deletions, duplications, inversion and translocations), D ratio of telomere length (in terms of log10 of tumour to normal (paired) telomere length), and E somatic copy-number burden landscape. Overall genome instability emerged as key signature of therapy resistance in ER/PR+HER2- breast tumours. The group-wise median for all types of genome alterations is shown individually for treatment-sensitive and resistant recurrent tumours.