Fig. 2: Colony phenotypes and growth kinetics of the phage-resistant mutants and SCNJ1. | Communications Biology

Fig. 2: Colony phenotypes and growth kinetics of the phage-resistant mutants and SCNJ1.

From: Capsule mutations serve as a key strategy of phage resistance evolution of K54 hypervirulent Klebsiella pneumoniae

Fig. 2

a Representative colony morphologies of K. pneumoniae SCNJ1 and representative strains of phage-resistant mutants on LB blood agar plates. Boxes indicate areas of increased magnification. The 1 cm scale is indicated. The colony morphology of all the phage-resistant mutants is presented in Supplementary Fig. 5. b The area under the growth curve of SCNJ1 and phage-resistant mutants. The presented data, shown as mean ± SD (n = 3), are from a representative experiment. The growth curves were converted into AUC (Area Under the Curve) by GraphPad Prism 10.1.2 to evaluate the growth abilities of SCNJ1 and the page-resistant mutants. Statistical significance was evaluated using one-way ANOVA and Dunnett’s multiple comparisons test was further conducted on ANOVA [For the CM group, F (10, 22) = 32.55, p < 0.0001; For the ZM group, F (9, 20) = 6.596, p = 0.0002; For the CR group, F (9, 20) = 0.8735, p = 0.5633; For the ZR group, F (9, 20) = 7.586, p < 0.0.0001]. The growth curves of SCNJ1 and phage-resistant mutants are presented in Supplementary Fig. 3.

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