Fig. 1: XRN1 is required for proliferation of a subset of cancer cell lines. | Communications Biology

Fig. 1: XRN1 is required for proliferation of a subset of cancer cell lines.

From: Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor

Fig. 1: XRN1 is required for proliferation of a subset of cancer cell lines.

a Pooled screen (Depmap 23Q4) results for XRN1 across 1100 cancer cell lines. b Colony formation in sensitive (red) and insensitive (blue) NSCLC cell lines after CRISPR knockout (KO) of XRN1 or a positive control. c Normalized proliferation of NSCLC cell lines after 12 days of CRISPR KO of XRN1 (gray bars) or positive control POL2RL (white bars). Error bars represent standard deviation of 3 replicates. d Apoptosis (normalized to uninfected control cells) as assessed by a caspase 3/7 luminescent assay in NCI-H1703 or NCI-H838 cell lines after 7 days of XRN1 CRISPR knockout (black bars: Non-targeting control; gray bars: XRN1 knockout). Error bars represent standard deviation of 3 replicates.

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