Fig. 1: Schematic diagrammatic representation of the proposed hypothesis. | Communications Biology

Fig. 1: Schematic diagrammatic representation of the proposed hypothesis.

From: Modulation of Sel1L can alleviate altered ER homeostasis towards white matter damage in CKD-stroke complex

Fig. 1

A Once CKD occurs, it can increase homocysteine level in brain. As a result, stroke can happen. Hyperhomocysteinemia results in impaired endoplasmic reticulum (ER) homeostasis via decreased Sel1L expression leading to ER stress mediated halt in oligodendrocyte maturation. Therefore, it is hypothesized that, ER homeostasis perturbation can exacerbate white matter damage towards neurodegeneration in CKD-Stroke complex (Created in BioRender. https://BioRender.com/72a8jmq). B Summary of experimental design. (Created in BioRender. https://BioRender.com/jro512v).

Back to article page