Fig. 5: The impact of chromosomal rearrangements on host cells. | Communications Biology

Fig. 5: The impact of chromosomal rearrangements on host cells.

From: Enhancing recombinant protein production through Cre-loxP mediated chromosomal rearrangement evolution in Kluyveromyces marxianus

Fig. 5

A Comparison of recombinant protein LBA production in engineered strains before and after chromosomal rearrangement. B Comparison of LBA production in constructed strains before and after chromosomal rearrangement, founded on the CYR1N1546K mutation. C Relative fluorescence intensity of engineered strains before and after chromosomal rearrangement. D Comparison of growth curves between engineered strains before and after chromosomal rearrangements. E Enriched GO pathways of differentially expressed genes in Inv-45. Red and green bars represent the upregulated and downregulated genes, respectively. F Enriched GO pathways of differentially expressed genes in Tra-23. Purple and blue bars represent the upregulated and downregulated genes, respectively. Values are presented as average ± SD, n = 3. **: p < 0.01, ***: p < 0.001.

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