Fig. 6: Cascade influence of Chr VIII inversion on host cells.

A Cellular processes associated with differentially expressed genes on Chr VIII resulting from inversion. Chr VIII and Chr VIII’ represent chromosome VIII before and after the inversion, respectively. A total of 33 differentially expressed genes located on the rearranged Chr VIII are illustrated, with orange representing upregulation and green representing downregulation. The distance of each gene from the rearrangement site is provided below. The letters in each gene serve as an index for the cellular pathways in which it primarily participates. The red font highlights the key cellular processes. B Inversion-induced changes in global cellular metabolic pathways. This focuses on glucose metabolism. The blue circles represent metabolites, the arrows indicate metabolic reactions, and the rectangles represent differentially expressed gene involved in these reactions. Orange indicates upregulation, green indicates downregulation, and pink represents enhanced pathway. C The levels of cAMP, acetyl-CoA, and ATP before and after the inversion. Values are presented as average ± SD, n = 3. *: p < 0.05, ****: p < 0.0001. D The H₂O₂ resistance before and after the inversion.