Fig. 4: RFCS differences among AD, MCI, and CU. | Communications Biology

Fig. 4: RFCS differences among AD, MCI, and CU.

From: White matter dysfunction in Alzheimer’s disease is associated with disease-related transcriptomic signatures

Fig. 4: RFCS differences among AD, MCI, and CU.The alternative text for this image may have been generated using AI.

a, b The altered RFCS among the three groups and the results of post hoc analysis within WM and GM, respectively. Regional colors indicate the positive (red) or negative (blue) statistical value. FDR correction was used for multiple comparisons with P < 0.05. c The first component (PLS1) for predicting WM RFCS explained 65.72% of the variance (permutation test, 10,000 times, P = 0.0022). d Strong spatial correlation between the group difference in WM RFCS and PLS1 score (Spearman’s r = 0.8107, P < 0.001). RFCS regional functional connectivity strength; GM gray matter; WM white matter; AD Alzheimer’s disease; MCI mild cognitive impairment; CU cognitively unimpaired.

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