Table 1 CD Markers Expressed in ADMSCS And Their Biological and Potential Therapeutic Functions
From: Adipose-derived mesenchymal stromal/stem cells in type 1 diabetes treatment
Cell Surface Marker | Gene | Function | Potential Therapeutic Activitya | References |
|---|---|---|---|---|
CD13 | ANPEP | Aids in the final digestion of peptides generated from the hydrolysis of proteins by gastric and pancreatic proteases | Tissue regeneration and repair | |
CD29 | ITBG1 | Cell adhesion Recognition in embryogenesis, homeostasis, tissue repair, immune response, and metastatic diffusion of cancer cells | Aids in multipotent differentiation Tissue repair Immune response Hemostasis | |
CD44 | CD44 | Cell-cell interactions Cell adhesion Cell migration | Promotes uptake of hyaluronic acid during inflammation (Anti-inflammatory) Immunoregulation\ | |
CD73 | NT5E | Determinants of lymphocyte differentiation Catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides | Immunosuppression of effector T-cells | |
CD90 | THY1 | Cell adhesion Cell communication | Cell proliferation Tissue repair | |
CD105 | ENG | Enables protein homodimerization activity and transforming growth factor beta binding activity Circulatory system development Positive regulation of cell differentiation Regulation of gene expression | Angiogenesis Cardiac regeneration | |
CD166 | ALCAM | Cell adhesion and migration Binds to T-cell differentiation antigen CD6 | Chondrogenic differentiation | |
CD34 | CD34 | May play a role in the attachment of stem cells to the bone marrow extracellular matrix or stromal cells | Potential in transplantation success | |
CD59 | CD59 | Inhibitor of the complement membrane attack complex Activates T cells through signal transduction pathway Encodes a cell surface glycoprotein that regulates complement-mediated cell lysis | Protect MSCs against complement action Anti-apoptotic | |
CD39 | ENTPD1 | Encodes plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP Produces adenosine with CD73 | Immunoregulation of effector T-cells | |
CD146 | MCAM | Involved in glomerular filtration and vascular wound healing Acts upstream of or within angiogenesis | Chondrogenesis Angiogenesis | |
CD71 | TFRC | Encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis Required for erythropoiesis and neurologic development | Erythropoiesis | |
CD201 | PROCR | Encodes a receptor for activated protein C | Improved engraftment | |
CD49e | ITGA5 | Cell surface adhesion Cell signaling | Cell surface adhesion | |
CD45 | PTPRC | Encodes a protein tyrosine phosphatase that regulates T- and B-cell antigen receptors | Immunosuppression | |
CD47 | CD47 | Encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to the extracellular matrix May play a role in membrane transport and signal transduction | Immunomodulation |
