Fig. 2: EV-D68 B3 VLP is structurally similar to InVP.
From: Structural insights from vaccine candidates for EV-D68
a Surface-rendered representation showing the overall structure of EV-D68 B3 InVP. The VP1, VP2, and VP3 are forest green, orange red, and blue, respectively. b Outlined icosahedral asymmetric unit of EV-D68 B3 InVP, showing the icosahedral symmetry axes (i2, i3, and i5) and quasi-symmetry axis (q3). c B3 InVP density maps are colored by radius to particle center. The color key shows the radius range from 100 Å to 155 Å. The particle mean diameter is 255 Å. d Alignment of icosahedral asymmetric unit. B3 VLP is colored in gray. VP4 was present in B3 InVP but not captured in B3 VLP. e Alignment with B3 InVP and VLP VP1 domain. RMSD is calculated based on the C-alpha atom pairs after alignment. f B3 InVP and VLP VP1 alignment at fivefold axis. Black dashed box highlights the DE loop different organization in B3 InVP and VLP. g Alignment with B3 InVP and VLP VP2-VP3 domain. h B3 VLP and InVP VP0 and VP3 alignment at threefold axis. Black dashed box highlights the similar HI loop organization in B3 InVP and VLP.
