Fig. 6: Proposed model of BmMasc-dependent BmdsxM splicing.
From: The Masc–PSI complex directly induces male-type doublesex splicing in silkworms
In B. mori males, the BmMasc–BmPSI protein complex binds to the adjacent region of the female-specific exons of Bmdsx pre-mRNA and induces exon skipping, resulting in the production of BmdsxM. In females, BmPSI is present but BmMasc is downregulated by W-linked Fem piRNA, resulting in low-level accumulation of the masculinizing complex.
