Fig. 3: CCDC91 promotes cell proliferation in vivo. | Communications Biology

Fig. 3: CCDC91 promotes cell proliferation in vivo.

From: HBV DNA integration gene CCDC91 is oncogenic and a potential therapeutic target for hepatocellular carcinoma

Fig. 3

A–C The subcutaneous tumor model formed by Huh-7-shCCDC91 and control Huh-7-SC cells in BALB/c nude mice (n = 5 per group). A The tumor growth curves based on tumor sizes measured at a 5-day interval. B Representative images of tumors at the time of sacrifice 36 days post tumor cells inoculation. C The tumor weights at the time of sacrifice. D, E The subcutaneous tumor model formed by HepG2-CCDC91 and control HepG2-VC cells in BALB/c nude mice. Representative images were shown (D) and the tumors with xenografts were weighted (E) (n = 5, respectively). F Representative images of IHC staining of CCDC91 and Ki-67 in the HCC tumors. G Quantification of the percentage of Ki-67-positive cells and CCDC91-positive cells. Statistical analysis was performed using Student’s t test in (C, E, and G). Two-way ANOVA was used for tumor volume in (A). Data represents mean ± SEM.*, p < 0.05; **, p < 0.01; ***, p < 0.001.

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