Fig. 6: Transcriptome analysis of the Rv3134c-Rv3135-Rv3136 locus showing the gene expression of ppe50 variants.
From: PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis
Transcriptome RNA-Seq reads from representative MTBC lineages for the Rv3134c, Rv3135 (ppe50) and Rv3136 (ppe51) genes were aligned to a reference locus containing the ppe50-439 gene (lineage L4.2.1.1), since this is the longest ppe50 gene. ppe50 variant genes were shown to be expressed and this matched their sequence length. Transcriptome analysis not performed on ppe50-268 from lineage L7. No expression was observed for all lineages where ppe50 was deleted. Depth: Log scale of counts of transcript reads observed. x-axis scale: 1 kilobase increments for the locus.
