Fig. 3: Dysregulated proteins of microtubule cytoskeleton organization and translation in Eml1 cKO neural progenitor cells.
From: Loss of Eml1 alters microtubule-associated protein networks in mouse brain heterotopia
A Volcano plots display proteins quantified in the neuronal progenitor cell proteome, with the x-axis showing log₂ (Fold Change) Eml1 cKO/control and the y-axis representing −log10(p-value) from the t-test. Gray dots indicate unchanged proteins, while significantly downregulated and upregulated proteins are shown in blue and red, respectively. Black vertical lines indicate the log₂ (Fold Change) threshold (±0.2), and the horizontal line marks the significance cutoff (p = 0.05). Proteins belonging to “Microtubule cytoskeleton organization” and “Translation” are outlined in black. B Microtubule cytoskeleton organization proteins and protein translation proteins were selected from the dysregulated list of 266 proteins using UniProt biological processes. Microtubule cytoskeleton organization was clustered into three groups: spindle organization, organelle organization, and organelle transport along microtubules. The proteins in protein metabolic processes were clustered into positive regulation of translation and macromolecule biosynthetic processes subgroups. Red circles represent upregulated proteins, and blue circles represent downregulated proteins in Eml1 cKO neural progenitor cells. Proteins localized to the microtubule organizing center (MTOC) are highlighted in gray, and ribosomal proteins are highlighted in orange.
