Fig. 2: Lack of fortilin in MФ ameliorates atherosclerosis. | Communications Biology

Fig. 2: Lack of fortilin in MФ ameliorates atherosclerosis.

From: Fortilin deficiency induces anti-atherosclerotic phenotypes in macrophages and protects hypercholesterolemic mice against atherosclerosis

Fig. 2

TNF-α tumor necrosis factor-α, IFN-ϒ interferon-ϒ, IL-23 interleukin 23, TGF-β1 transforming growth factor β1, TGF-β2 transforming growth factor β2. a En face atherosclerosis assay showing significantly less atherosclerosis in fortilinKO-MΦ-HC mice than in fortilinWT-MΦ-HC mice. b Cross-sectional atherosclerosis assay showing significantly less atherosclerosis in fortilinKO-MΦ-HC mice than in fortilinWT-MΦ-HC mice. Quantitative multiplex cytokine assays of (c) TNF-α, (d) IFN-ϒ, (e) IL-23, (f) TGFβ-1, and (g) TGF-β2. The scale bar in (b) equals 100 µm. Data are expressed as mean ± s.d., P values were determined by either two-sided Student’s t test (a, b, f, g) or two-tailed Mann–Whitney test (c, d, e).

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