Fig. 8: Effect of IGF2 overexpression and knockdown on metabolic profiles in adipose tissues.
From: Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues
A, B Principal Component Analysis (PCA) of IGF2 overexpression and knockdown, respectively. C, D Heatmap representation of peak intensity z-scores in IGF2 overexpression and knockdown adipose tissues, respectively. E, F Pathway analysis for differential metabolites conducted with MetaboAnalyst 5.0. in IGF2 overexpression and knockdown adipose tissues, respectively. G The main biological processes of de novo lipogenesis and lipolysis and annotated differential metabolites at their corresponding positions, the upregulated (blue frame with red font) and downregulated (blue frame with green font) differential metabolites produced by IGF2 overexpression mice, the upregulated (yellow frame with red font) and downregulated (yellow frame with green font) differential metabolites produced by IGF2 knockdown mice.
