Table 1 Clinical characteristics of the participants included in the validation study

From: Paradoxical regulation of IGF2 in promoting lipid metabolism in adipose tissues

Characteristic

Total

Non-MetS

MetS

p value

N

200

150

50

 

Serum IGF2 (ng/mL) by LC-MS/MS

204.84 ± 105.34

209.58 ± 99.93

190.64 ± 120.11

0.2722

Serum IGF2 (ng/mL) by ELISA

197.91 ± 128.92

184.67 ± 91.52

237.63 ± 120.56

0.0619

Age (years)

59.40 ± 6.72

58.33 ± 6.16

59.82 ± 6.18

0.782

Male, n (%)

103 (51.50)

73 (48.67)

30 (60.00)

0.332

Current smoker, n (%)

89 (44.50)

61 (40.67)

28 (56.00)

0.315

Alcohol drinker, n (%)

93 (46.50)

57 (38.00)

36 (72.00)

<0.001

BMI (kg/m2)

24.66 ± 3.16

22.87 ± 2.36

26.33 ± 2.63

<0.001

WC (cm)

81.52 (69.23–92.20)

73.84 (68.13–84.15)

86.96 (84.23–92.10)

<0.001

WHR

0.90 (0.82–0.99)

0.84 (0.81–0.89)

0.94 (0.89–0.98)

<0.001

Body fat (%)

29.74 ± 6.49

27.24 ± 5.86

30.90 ± 6.50

0.001

SBP (mmHg)

123.55 (110.20–141.57)

116.78 (110.120–123.43)

125.48 (118.85–142.56)

<0.001

DBP (mmHg)

81.34 ± 9.23

78.45 ± 7.45

84.62 ± 8.64

<0.001

HbA1c (%)

5.86 (5.45–6.43)

5.49 (5.23–5.68)

5.73 (5.41–6.26)

0.017

ALT (U/l)

18.20 (14.010–26.15)

17.50 (10.56–25.56)

29.75 (16.95–33.45)

0.004

AST (U/l)

19.34 (16.23–23.04)

19.84 (14.54–24.86)

23.54 (17.43–29.67)

0.134

FPG (mmol/L)

5.35 (4.54–5.76)

6.71 (6.46–7.56)

7.35 (6.75–7.69)

0.003

2 h postprandial glucose (mmol/L)

6.13 (4.86–7.43)

7.49 (6.35–8.64)

10.23 (7.53–15.54)

<0.001

FINS (μU/mL)

19.64 (14.24–22.87)

18.34 (13.45–22.34)

28.45 (19.53–34.34)

<0.001

2 h INS (μU/mL)

57.67 (37.23–87.97)

54.43 (36.25–83.86)

81.95 (47.34–177.25)

<0.001

HOMA-IR

3.28 (2.73–4.45)

3.56 (2.34–4.88)

5.53 (4.56–8.34)

<0.001

TC (mmol/L)

5.45 ± 1.23

5.32 ± 0.86

5.78 ± 1.15

0.268

LDL-c (mmol/L)

2.34 (2.20–2.62)

2.33 (1.92–2.75)

2.34 (1.72–2.90)

0.781

HDL-c (mmol/L)

1.28 (1.11–1.67)

1.65 (1.31–1.98)

1.18 (0.86–1.55)

<0.001

TG (mmol/L)

1.78 (0.89–2.42)

1.14 (0.67–1.48)

3.245 (1.76–3.40)

<0.001

SFA (cm2)

153.43 (123.45–193.56)

150.70 (105.43–205.16)

170.49 (122.76–228.28)

<0.001

VFA (cm2)

78.60 (47.34–132.86)

58.65 (23.56–89.64)

138.25 (72.07–164.48)

<0.001

  1. Data are presented as the mean ± standard deviation, the median with 25–75% interquartile range or n (%).
  2. BMI body mass index, WC waist circumference, WHR waist-to-hip ratio, SBP systolic blood pressure, DBP diastolic blood pressure, HbA1c hemoglobin A1c, ALT alanine transaminase, AST aspartate transaminase, FPG fasting plasma glucose, FINS fasting serum insulin levels, 2 h INS 2 h postprandial insulin levels, HOMA-IR homeostasis model assessment-insulin resistance, TC total cholesterol, LDL-c low-density lipoprotein-cholesterol, HDL-c high density lipoprotein-cholesterol, TG triglyceride, SFA abdominal subcutaneous fat area, VFA visceral fat area.
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