Fig. 4: Enrichment analyses of the genes associated with ALS epicenter map.
From: Network spreading and local biological vulnerability in amyotrophic lateral sclerosis
a Top 30 biological process terms from the GO Consortium knowledge base associated with gene sets correlated with the ALS epicenter likelihood map, shown in Fig. 2c214. b All cellular components terms from the GO Consortium knowledge base that are significantly enriched in gene sets correlated with the ALS epicenter likelihood map214. Terms in both categories are ordered by their category scores (c-scores). c Cell type enrichment analysis of ALS epicenter map reveals significant hits for pericytes and endothelial cells87. Used gene markers for endothelial cells and pericytes are shown in Fig. S6. The graphical representation of pericytes and endothelial cells is created in BioRender (Farahani, A. (2025) https://BioRender.com/xswclks). For more details, including gene markers for each biological process, cellular component, and cell type, exact c-score values, and corresponding p-values, refer to the Supplementary Data 1: Gene-enrichment.
