Fig. 1: Immune cell profiling and communication dynamics in AAA patients: T cell subsets, Treg activity, and pathway expression revealed by scRNA-seq. | Communications Biology

Fig. 1: Immune cell profiling and communication dynamics in AAA patients: T cell subsets, Treg activity, and pathway expression revealed by scRNA-seq.

From: Targeting VCAM-1 with chimeric antigen receptor and regulatory T cell for abdominal aortic aneurysm treatment

Fig. 1

Proportions of T cells, B cells, and plasma cells in arterial tissues from 7 AAA patients and blood samples from 6 AAA patients (A). UMAP plots of all T cell types in blood samples from AAA (left) and HC (middle). We also showing the distribution proportions of cell types and Treg cells are highlighted in red (B). UMAP plots of all T cell types in tissue samples from AAA (left) and HC (middle) and Treg cells are also highlighted in red (C). Dot plot showing increasing and decreasing trends of communication between Tregs from different sources (D). Signal communication activity of Tregs from PBMC and arterial tissue (E). Two overall signal patterns show the relative communication intensity between T cells from controls and T cells from AAA (F). Communication intensity of three different pathways (IL16, SELPLG, MHC-II) within different types of T cells (G). Three violin plots (H, I) represent gene expression in the three pathways. Expression in different types of T cells (tissue and PBMC cells) from AAA is shown in pink, while expression in the control group is shown in dark green.

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