Fig. 1: Pheromonal components and their biosynthetic genes from P. pacificus. | Communications Biology

Fig. 1: Pheromonal components and their biosynthetic genes from P. pacificus.

From: Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus

Fig. 1

a Chemical structures of simple ascarosides including ascr#9, ascr#12, and ascr#1. b Structures of chemically modified modular signaling molecules (e.g., UBAS, DASC, and NPAR pheromones). c 20 out of 76 candidate genes (Supplementary Tables 1 and 2) with homology to Ppa-uar-149 were knocked out by CRISPR/Cas9, from which Ppa-uar-5, Ppa-uar-12, and Ppa-uar-6 genes were shown to regulate the biosynthesis of UBAS, DASC and NPAR pheromones, respectively. d A workflow for screening carboxylesterase genes that are responsible for the biosynthesis of modular pheromones from P. pacificus.

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