Table 1 Antibacterial spectrum of ILE and ILF

From: Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria

Strains or drug combinations

ILE MIC (µg mL−1)

ILF MIC (µg mL−1)

FICI

AlRa

0.05a

1.25a

AlRv

0.05a

ND

AlMsm

0.0625a

2.5a

AlMab

1a

20a

AlMmr

0.08a

0.625a

H37Rv

0.025b

2.5b

K11c

0.025–0.05b

ND

K12c

0.025b

ND

K13c

0.01b

ND

K14c

0.01b

ND

K16c

0.05b

ND

K17c

0.01b

ND

K18c

0.025–0.05b

ND

K19c

0.01b

ND

K20c

0.05b

ND

Staphylococcus aureus

>128

>128

Acinetobacter baumannii

>128

>128

Enterococcus faecium

>128

>128

Klebsiella pneumoniae

>128

>128

Pseudomonas aeruginosa

>128

>128

ILE + RIF

0.3125a

ILE + INH

0.625a

ILE + EMB

0.5625a

ILE + STR

1a

ILE + CFZ

1a

ILE + BDQ

0.62a

ILE + TB47

0.3125a

ILF + RIF

1.0625a

ILF + INH

0.3125a

ILF + EMB

1a

ILF + STR

1a

ILF + CFZ

0.63a

ILF + BDQ

1a

ILF + TB47

0.3125a

  1. − Not applicable, ND not detected, FICI fractional inhibitory concentration index.
  2. aMICs obtained by detection of relative light units.
  3. bMICs obtained by the microplate alamar blue assay.
  4. cClinical resistant Mtb.