Table 3 MICs of ILE and ILF against gene edited strains and corresponding spontaneous mutants

Mab^wt

/

1

20

Mab^R2a

ClpC1^wt to ClpC1^F2L

4 / (4)

> 128 / (> 6)

Mab-C1^F2L

ClpC1^wt to ClpC1^F2L

8 / (8)

> 128 / (> 6)

Mab^R1a

ClpX^wt to ClpX^P30H

> 128 / (> 128)

> 128 / (> 6)

Mab-X^P30H

ClpX^wt to ClpX^P30H

> 128 / (> 128)

> 128 / (> 6)

Msm^wt

/

0.0625

2.5

Msm^R2b

ClpC1^wt to ClpC1^F2C

0.25 / (4)

10 / (4)

Msm-C1^F2C

ClpC1^wt to ClpC1^F2C

0.5 / (8)

20 / (8)

Msm^R3b

ClpC1^wt to ClpC1^M1-L-F2

1 / (16)

20 / (8)

Msm-C1^M1-L-F2

ClpC1^wt to ClpC1^M1-L-F2

0.25 / (4)

16 / (6.4)

Msm^R8b

ClpC1^wt to ClpC1^F2S ClpC1^wt to ClpC1^I197N

0.25 / (4)

10 / (4)

Msm-C1^I197N

ClpC1^wt to ClpC1^I197N

0.0625 / (1)

2.5 / (1)