Table 1 Transcriptomic differences between PKH2hi and PKH2low macrophages of genes that are down-regulated upon Ly6C+ monocytes conversion to the Ly6C- phenotype32

From: IFN-β and ARTS deficiency promote the generation of hyper-efferocytic Ly6C+ macrophages in resolving inflammation in male mice

Gene

PKH2hi Macrophages

PKH2low Macrophages

Fold change (log 2)

Q value

Cebpe

1.84625

1.71813

22.1857

37.3552

4.06216

0.000617

Ly6c2

20.0821

18.7825

174.77

287.827

3.57323

0.000617

Mmp8

3.07353

17.9474

49.5149

124.769

3.05154

0.000617

Sell

29.9319

36.0813

135.501

277.244

2.64443

0.000617

Ccr2

82.7926

124.046

439.597

491.833

2.17094

0.000617

Fcrls

4.02183

3.35151

10.1622

8.24292

1.31972

0.011855

Foxm1a

3.69174

3.96529

0.537529

0.565516

−2.79529

0.004085

  1. Only genes whose expression was downregulated in both the bone marrow and blood are displayed. Table 1 depicts genes that changed dramatically ( > 2-fold change) and in a statistically significant manner (Q < 0.05).
  2. aFoxm1 reduction in blood monocytes8 was minimal.
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