Fig. 8: KAT8-mediated H3K27ac modification upregulates Hk2, Pk, and Ldh in UV-WSSV-trained shrimp. | Communications Biology

Fig. 8: KAT8-mediated H3K27ac modification upregulates Hk2, Pk, and Ldh in UV-WSSV-trained shrimp.

From: Histone H3K27 acetylation mediated by KAT8 maintains antiviral trained immunity in shrimp induced by inactivated white spot syndrome virus

Fig. 8

a–c Integrative Genomics Viewer (IGV) tracks showing the H3K27ac modification peak in the TSSs of Hk2 (a), Pk (b) and Ldh (c) in UV-WSSV-trained shrimp (with PBS as the control). The arrows indicate the peak regions of H3K27ac around the TSS and the enrichment at the target gene promoters. The number represents the peak height. d–f Effects of UV-WSSV training on the expression of Hk2 (d), Pk (e) and Ldh (f) analyzed by ChIP-qPCR. g–i Effects of Kat8-RNAi on the expression of Hk2 (g), Pk (h) and Ldh (i) analyzed by ChIP-qPCR. The data are presented as the mean ± SD (n = 3). Statistical significance was analyzed by Student’s t test for pairwise comparisons, and p < 0.05 was considered a significant difference.

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