Fig. 9: Interaction between PLAGL2 and MFSD12.
From: MFSD12, transcriptionally regulated by PLAGL2, promotes bladder cancer progression
A MFSD12 mRNA expression in UMUC3 and 5637 cells after knockdown of the members of the PLAGL gene family (PLAG1, PLAGL1, and PLAGL2). B MFSD12 mRNA expression in UMUC3 and 5637 cells after PLAGL2 overexpression. C PLAGL2 binding sites on the MFSD12 promoter were predicted based on the JASPAR database (https://jaspar.elixir.no/). D Activities of the MFSD12 promoter of different lengths were detected by dual-luciferase reporter assay. E, F ChIP-PCR analysis of the interaction between PLAGL2 and the MFSD12 promoter. Data are means ± SD. Statistical analysis was performed using Student’s t-test or one-way ANOVA.
