Fig. 6: Kv11.1 activator NS1643 arrests lung tumor growth. | Communications Biology

Fig. 6: Kv11.1 activator NS1643 arrests lung tumor growth.

From: Activation of Kv11.1 potassium channel suppresses non-small cell lung cancer growth by promoting c-Myc degradation

Fig. 6

A Proliferation assay performed with Lewis lung carcinoma cells exposed to NS1643 (25–50 mM/24 h). Inset Western blot indicates expression of the Kv11.1 channel. B Effects of NS1643 injection (6 mg/Kg; 3 days interval of intraperitoneal injection) on LLC tumor growth in LLC syngeneic model. C, D Size and weight comparison of LLC tumors dissected from control (DMSO) or test (NS1643) mice. E Representative images of IHC staining of Ki-67 and F c-Myc (A) in control vs NS1643 treated LLC tumor model. Scale bar = 50 µm, magnification ×400. *, ** statistically significant (P < 0.05 or P < 0.01, respectively).

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