Fig. 5: Determination of mutant strains virulence.
From: A critical role of copper homeostasis in the virulence of Klebsiella pneumoniae
a Schematic representation of the mouse bloodstream infection model (12 h). Created in BioRender. Han, M. (2025) https://BioRender.com/8wjsnkw. b Bacterial counts in mouse organs. Following 12 h infection, the liver, spleen, lungs, and kidneys were harvested, weighed, homogenized, and plated to quantify bacterial load. n = 3 biological replicates. Two-way ANOVA with multiple comparisons. Histopathological changes due to inflammation in mouse (c) liver and (d) lung tissues (12 h post-infection). Boxes indicate enlarged views. Scale bars: 200 µm (50× magnification), 100 µm (100× magnification). Data are presented as mean ± SEM, *p < 0.05, **p < 0.01, ****p < 0.0001, ns indicates not significant.
