Fig. 3: Fetal cCMV infection and pathology. | Communications Biology

Fig. 3: Fetal cCMV infection and pathology.

From: A rhesus macaque model of congenital cytomegalovirus infection reveals a spectrum of vertical transmission outcomes

Fig. 3: Fetal cCMV infection and pathology.

A RhCMV DNA copies in fetal tissues of dams 001-101, 001-107, and 001-110. Mean copy number of 12 PCR replicates shown and expressed per µg of input DNA for urine and tissues, or per mL of sample for fetal plasma and cord blood. Gray boxes and ND indicate no sample collected. Tissues in which no viral DNA was detected are denoted with “0” and a white box. Representative RhCMV ISH of fetal tissues from dam 001-101. Rare RhCMV RNA positive cells (green, arrows) were detected in inflamed sections of hypothalamus (B) and lung (C) with RNAscope. Bar = 50 μm. D Heatmap showing number of RhCMV-positive cells per fetal tissue sample from dam 001-101. Histopathology of fetal tissues from dam 001-101 showing E Glial nodules in brainstem; F Hypothalamus lesions included cerebral vessels with mononuclear perivascular cuffs; G Lung, alveolar septa were thickened by inflammatory cells with rafts of neutrophils (inset) within alveoli. Bar = 100μm.

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