Fig. 6: Acute host response to primary RhCMV infection.

A Mean absolute counts of circulating total white blood cells (WBC), neutrophils, lymphocytes, and monocytes from day 0 to day 98 post-infection (PI). Gray lines denote AF– dams (n = 7), while red lines denote AF+ dams (n = 5). B Heatmap illustrating rank values of median maternal plasma concentrations of cytokines between 0 and 14 days PI. Cytokines measured by a 33-plex NHP Luminex assay. C Box and whisker plot illustrating area under the curve (AUC) of maternal plasma TNF-alpha concentrations during first 2 weeks PI. Red icons denote AF+ dams (n = 5) and black icons refer to AF– dams (n = 7). The open red circle denotes dam 001-101. Significance determined by Wilcoxon rank sum test.