Fig. 2: MERSmut-CoV M protein has significant structural differences from SARS-CoV-2 and SARS-CoV.
From: Structural insights into MERS and SARS coronavirus membrane proteins
a Superimposed structural comparison of apo SARS-CoV-2 M protein (gray, PDB:7VGS) versus apo SARS-CoV M protein (orange, PDB: 9NZ4) in cartoon ribbon representation, highlighting JNJ-9676 binding pocket residues as sticks and lines. Key residue differences are highlighted with (*). b Superimposed structural comparison of apo SARS-CoV-2 (protomer A gray, protomer B blue—gray, PDB: 7VGS), apo SARS-CoV (protomer A orange, protomer B green, PDB: 9ZN4) and apo MERSmut-CoV (protomer A cyan, protomer B, blue, PDB: 9NZ5) in cartoon ribbon representation. SARS-CoV and MERSmut-CoV M proteins were aligned to SARS-CoV-2 (PDB: 7VGS). The N-terminal regions of the TMs are highlighted. c Superimposed JNJ-9676 binding pocket formed by protomer B TM1, protomer A TM2 and TM3 shown by cartoon ribbon representation (coloring as shown in (b)), highlighting key differences in the binding pocket residues shown as sticks and lines. d, Two-dimensional (2D) interaction pattern of JNJ-9676 and SARS-CoV-2 M protein (protomer A: gray, protomer B: blue-gray), and SARS-CoV M protein (protomer A: orange, protomer B: green), highlighting key residue differences as shown in (b), with MERS-CoV M protein (protomer A: cyan, protomer B: blue) differences shown with (*), and interactions are indicated with dashed lines (π-π stacking: purple).
