Fig. 2: MIR22HG mediates the function of HSCR-EVs. | Communications Biology

Fig. 2: MIR22HG mediates the function of HSCR-EVs.

From: Extracellular vesicle-mediated transfer of MIR22HG inhibits the colonization of enteric neural crest cells in the colon by decreasing MPP3 expression

Fig. 2

A MIR22HG was significantly upregulated in HSCR-EVs compared to that in Ctrl-EVs (n = 12). B MIR22HG exhibited higher expression in the stegnotic segments in children with HSCR (HSCR-S) compared to that in control tissues or the dilated segments from children with HSCR (HSCR-D) (n = 21). Overexpression of MIR22HG inhibited ENCC migration (n = 5, scale bar=100 μm) (C), proliferation (n = 5, scale bar=50 μm) (D), and cytoskeleton formation (n = 3, scale bar=50 μm) (E). Data are mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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