Fig. 5: Bland-Altman plots relating ground truth and estimated parameters for all tested dMRI protocols.

The plots relate the average values between estimated/ground truth parameters (x-axis) to their difference (y-axis), and include the bias and upper/lower limit-of-agreement (LOA) (n = 4050 unique data points from 18 independently-simulated substrates per subplot). Top row (a–e): PGSE-in protocol; mid row (f–j): TRSE protocol; bottom row (k–o): PGSE-ex protocol. First column form left (a, f, k): IC fraction fin; second column form left (b, g, l): CS index vCScyl; third column form left (c, h, m): intrinsic IC diffusivity D0∣in; fourth column form left (d, i, n): intrinsic EC diffusivity D0∣ex; fifth column form left (e, j, o): cell membrane permeability parameter κ.