Table 1 Properties of the substrates used for MC simulations, drawn on histological tissue coming from liver tumour biopsies from 10 cancer patients

From: Histology-informed microstructural diffusion simulations for MRI cancer characterisation—the Histo-μSim framework

Substrate

Description of ROI

ROI area (μm2)

Cellularity (cells / mm2)

fin

mCS (μm)

varCS (μm2)

skewCS

vCSsph (μm)

vCScyl (μm)

Γ distribution shape

Γ distribution scale (μm)

Lumen fraction of EC space fl

Lumina diameters (μm)

1

non-cancerous liver, patient A

47,689

3921

0.773

15.3

14.2

−0.115

18.7

18.1

14.69

1.04

0.000

-

2

non-cancerous liver, patient A

59,248

4878

0.868

14.5

15.0

−0.156

18.1

17.4

12.32

1.18

0.000

-

3

non-cancerous liver, patient B

59,377

3907

0.827

15.9

15.9

−0.528

19.1

18.5

12.58

1.26

0.000

-

4

non-cancerous liver, patient B

69,172

4091

0.846

15.6

19.7

−0.283

19.9

19.1

9.69

1.60

0.000

-

5

CRC with lumina, patient C

23,752

8968

0.498

8.1

4.8

0.861

11.6

10.6

14.04

0.58

0.157

[27.7, 39.0]

6

CRC with fibrosis and lumina, patient C

90,130

2408

0.316

8.7

5.9

0.506

11.8

11.1

14.59

0.62

0.117

[27.8, 88.9]

7

CRC with lumina, patient C

39,305

10,508

0.523

7.7

4.9

0.349

10.3

9.7

11.56

0.66

0.512

[33.9, 57.9, 34.0, 67.8]

8

CRC with lumina, patient D

62,434

13,743

0.437

6.1

3.3

0.628

8.5

8.0

11.34

0.53

0.253

[42.9, 26.2, 23.1, 24.1, 57.4, 64.2]

9

CRC with fibrosis, patient E

56,891

3375

0.130

6.8

2.3

0.287

8.2

7.9

19.23

0.35

0.000

-

10

CRC and hepatocytes, patient A

49,637

6870

0.658

10.2

17.5

−0.191

14.7

14.1

4.56

2.23

0.000

-

11

CRC and hepatocytes, patient A

43,056

7873

0.730

10.4

9.7

0.230

14.0

13.2

10.20

1.02

0.000

-

12

CRC and hepatocytes, patient A

45,109

7737

0.831

11.1

11.9

0.396

15.4

14.5

10.12

1.10

0.000

-

13

HCC with necrosis, patient F

128,132

2622

0.117

7.1

5.2

0.786

10.9

9.9

9.79

0.73

0.000

-

14

HCC, patient G

62,088

5492

0.747

12.4

17.7

−0.004

17.3

16.3

7.43

1.67

0.000

-

15

HCC with necrosis, patient G

57,699

676

0.024

6.4

3.4

0.481

8.5

8.1

12.09

0.53

0.000

-

16

Melanoma, patient H

51,700

8704

0.718

9.9

5.5

−0.005

12.1

11.6

16.34

0.61

0.000

-

17

Breast cancer with fibrosis and necrosis, patient I

63,121

2139

0.076

6.4

3.2

0.614

8.6

8.2

13.20

0.49

0.000

-

18

Melanoma, patient J

41,632

11434

0.587

7.7

5.2

0.603

10.8

10.1

11.29

0.68

0.000

-

  1. Substrates 1 to 4 contain only non-cancerous hepatocytes. Substrates 5 to 9 contain colorectal cancer (CRC) tissue, featuring large luminal spaces or presence of fibrosis, as in substrate 6 and especially substrate 9. Substrates 10 to 12 contain a mix of non-cancerous and different concentrations of CRC cells. Substrates 13 to 15 are sampled from hepatocellular carcinoma (HCC) cases, with substrate 13 in particular containing HCC cells and necrosis, and substrate 15 taken from an area of extended necrosis with scattered cells and cell debris. Substrates 16 and 18 are ROIs of a melanoma liver metastasis. Finally, substrate 17 was taken from a breast cancer liver metastasis, and shows areas of necrosis and fibrosis. The patients’ ID was randomly generated.
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