Table 2 Mean values of metrics from Histo-μSim forward model 2 and from histology within different ROIs drawn on the breast, kidney and spleen tissue scanned ex vivo on a pre-clinical 9.4T MRI system
Description | fin∣histo | fin∣MC | vCSsph∣histo | vCScyl∣histo | mCShisto | vCScyl∣MC | κ |
|---|---|---|---|---|---|---|---|
[μm] | [μm] | [μm] | [μm] | [μm/s] | |||
ROI 1: Breast tumour - Week 9 (cellular area) | 0.70 | 0.56 | 8.6 | 8.4 | 7.5 | 12.5 | 21.7 |
ROI 2: Breast tumour - Week 14 (necrosis) | 0.03 | 0.08 | 4.5 | 4.4 | 4.0 | 10.0 | 4.1 |
ROI 3: Breast tumour - Week 14 (cellular area) | 0.72 | 0.48 | 10.4 | 10.1 | 9.0 | 12.0 | 24.8 |
ROI 4: Breast tumour - Week 11 (cellular area) | 0.64 | 0.61 | 8.7 | 8.4 | 7.2 | 12.7 | 23.7 |
ROI 5: Non-cancerous breast | 0.11 | 0.04 | 7.7 | 7.4 | 6.3 | 8.7 | 0.20 |
ROI 6: Breast tumour - Week 9 (cellular area) | 0.68 | 0.75 | 5.7 | 5.6 | 5.2 | 8.0 | 3.3 |
ROI 7: Breast tumour - Week 9 (cellular area) | 0.55 | 0.77 | 8.0 | 7.7 | 6.8 | 12.7 | 4.5 |
ROI 8: Breast tumour - Week 9 (cellular area) | 0.76 | 0.70 | 8.8 | 8.6 | 7.6 | 12.4 | 6.3 |
ROI 9: Breast tumour - Week 11 (cellular area) | 0.81 | 0.53 | 9.6 | 9.4 | 8.7 | 12.1 | 11.3 |
ROI 10: Breast tumour - Week 11 (cellular area) | 0.84 | 0.60 | 11.0 | 10.8 | 9.9 | 13.2 | 28.3 |
ROI 11: Breast tumour - Week 11 (cellular area) | 0.77 | 0.52 | 9.1 | 8.9 | 8.1 | 12.4 | 25.3 |
ROI 12: Breast tumour - Week 14 (necrosis) | 0.01 | 0.03 | 2.0 | 1.9 | 1.7 | 9.4 | 4.4 |
ROI 13: Breast tumour - Week 14 (cellular area) | 0.74 | 0.60 | 9.7 | 9.5 | 8.5 | 12.9 | 25.0 |
ROI 14: Breast tumour - Week 14 (cellular area) | 0.77 | 0.54 | 9.8 | 9.5 | 8.8 | 12.9 | 21.1 |
ROI 15: Injured kidney | 0.66 | 0.48 | 6.0 | 5.8 | 5.0 | 11.8 | 26.7 |
ROI 16: Healthy kidney | 0.82 | 0.10 | 11.8 | 11.6 | 10.1 | 11.6 | 17.3 |
ROI 17: Healthy spleen | 0.75 | 0.44 | 5.2 | 5.1 | 4.4 | 8.9 | 8.6 |
ROI 18: Splenomegaly | 0.64 | 0.41 | 4.7 | 4.6 | 4.0 | 8.3 | 0.50 |
