Fig. 2: Metabolomic and microbiota classifiers of horses with MetS.
From: Bile acids segregate metabolic syndrome in a cohort of 100 deeply phenotyped horses
A Violin plot of mean plasma deoxycholic acid (DCA) concentrations across the three sampling times grouped by regulated or insulin dysregulated (SMetS and MetS combined), showing median and range (P = 0.038). B Violin plot of mean plasma taurochendeoxycholic acid (TCDCA) concentrations across the three sampling times grouped by regulated or insulin dysregulated (SMetS and MetS separate), showing median and range (P = 0.039). C Dendrogram of hierarchical clustering based on outlier analysis of metabolites. More insulin dysregulated individuals segregated in clade 1, and more insulin-regulated individuals segregated in clade 2. Animals were classed as MetS (ID; red), SMetS (Seasonal; blue) or Regulated (green). D Heatmap of the top 20 metabolites used to cluster individuals by phenotype. E Box and whisker plots of Shannon diversity index across all sample time points, grouping by insulin-regulated and dysregulated, demonstrating at a community level, no differences in alpha diversity were detected by metabolic phenotype. F Box and whisker plots of Chao 1 diversity index across all sample time points, grouping by insulin-regulated and dysregulated demonstrating at a community level no differences in sample richness were detected by metabolic phenotype.
