Fig. 4: Manhattan plot of GERD GWAS with InsightGWAS-enhanced signal prioritization. | Communications Biology

Fig. 4: Manhattan plot of GERD GWAS with InsightGWAS-enhanced signal prioritization.

From: Transformer-based InsightGWAS improves GERD genetic discovery via pretraining on GWAS for major depressive disorder

Fig. 4: Manhattan plot of GERD GWAS with InsightGWAS-enhanced signal prioritization.

The plot displays −log10(p) association values for GERD from the GWAS by An et al., excluding 23andMe data. Genome-wide significance threshold (p < 5 × 10⁻8) is indicated by the red dashed line. Orange circles represent all variants prioritized by InsightGWAS, illustrating the complete set of SNPs ranked by the model as potentially trait-relevant. Independent association signals were then identified through LD clumping of these prioritized variants. Orange diamonds mark the independent lead loci that correspond to previously reported genome-wide significant regions from An et al1. and Ong et al8. Violet diamonds indicate newly identified independent loci highlighted by InsightGWAS that were not reported in prior GERD studies (Supplementary Data 3).

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