Fig. 7: Irisin effects on GC genomic effects and GR phosphorylation depend on integrin αVβ5 receptor. | Communications Biology

Fig. 7: Irisin effects on GC genomic effects and GR phosphorylation depend on integrin αVβ5 receptor.

From: Irisin regulates the phosphorylation of glucocorticoid receptor Ser212 and Ser234 and mediates glucocorticoid-induced muscle atrophy in mice

Fig. 7: Irisin effects on GC genomic effects and GR phosphorylation depend on integrin αVβ5 receptor.

A Western blot analyses of integrin αV, integrin β5 and GAPDH in Dex and irisin-administered myotubes. B Protein levels were analyzed, n = 4 independent replicates. C Western blot analyses of P-ERK, P-GR(Ser212), P-JNK (Thr183/Tyr185), P-GR(Ser234), IGF-1, MSTN and GAPDH in integrin αVβ5 inhibitor cliengitide treatment myotube. D–I Protein levels were analyzed, n = 4 independent replicates. Data are presented as means ± SEM. One-way ANOVA was used for statistical analysis (B), Two-way ANOVA was used for statistical analysis (D–I).

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