Fig. 1: Schematic overview of Tissue Contribution Index (TCI).
From: Tracing the tissue origin of cell-free DNA through open chromatin footprint
a Coverage pattern of highly and lowly expressed gene around transcriptional start site (TSS), identification of tissue-specific highly expressed genes (SH-genes), and the TSS coverage pattern of SH-genes for each tissue in plasma. b TCI calculation workflow for individual tissues. c Construction of baseline of plasma TCI in 460 healthy individuals, validation in plasma of pregnant women and organ transplant recipients and applications of TCI for cancer detection and tissue injury assessment. Some elements in (a, b) were created in BioRender. Li, L. (2025) https://BioRender.com/8hdbkw8.
