Fig. 3: TCI in pregnant women.
From: Tracing the tissue origin of cell-free DNA through open chromatin footprint
a The average Base Counts Per Million mapped bases (BCPM) profiles at single base pair resolution across 1,000 bp upstream and downstream of transcriptional start site (TSS) of placental tissue-specific highly expressed genes (SH-genes) in pregnant women grouped by fetal DNA fraction intervals. b Correlation between placenta Tissue Contribution Index (TCI) and fetal cfDNA fractions in 101 samples from pregnant women with male fetus. c Comparison of the correlations between fetal cfDNA fraction and plasma placental contribution predicted by TCI and OCF methods in simulation samples with different cfDNA amounts. Central dot in (c) indicate Pearson correlation coefficients, with two bars showing 95% confidence intervals. The shaded area in (a, b) represents the 95% confidence interval.
