Fig. 7: Liver, artery and lung Tissue Contribution Index (TCI) in plasma of COVID-19 patients.
From: Tracing the tissue origin of cell-free DNA through open chromatin footprint
a Boxplot of liver TCI in patients with normal serum lactate dehydrogenase (LDH) level and those with liver injury determined by high LDH (LDH ≥ 500 U/L). b Boxplot of liver TCI in patients with normal alanine aminotransferase (ALT) level (ALT < 80 U/L) and those with liver injury (ALT ≥ 80 U/L). c Receiver operator characteristic (ROC) analysis of liver TCI for discriminating between patients with liver injury (LDH ≥ 500 U/L or ALT ≥ 80 U/L) versus normal (LDH < 250 U/L and ALT < 40 U/L). d Boxplot of artery TCI for patients in the intensive care unit (ICU) and patients not in ICU (non-ICU). e Boxplot of artery TCI for patients with cured and deceased outcomes. f ROC analysis of artery TCI for distinguishing ICU/non-ICU status and cured-deceased outcomes. g Boxplot of lung TCI for patients in ICU and patients not in ICU. h Boxplot of lung TCI for patients with cured and deceased outcomes. i ROC analysis of lung TCI for distinguishing ICU/non-ICU status and cured-deceased outcomes. In ROC curves (c, f, i), square brackets indicate 95% confidence intervals for AUC values. In boxplots (a, b, d, e, g, h), red/blue dashed lines represent reference TCI limits (derived from 460 healthy controls).
