Fig. 8: Tissue Contribution Index (TCI) in cancer and healthy subjects.
From: Tracing the tissue origin of cell-free DNA through open chromatin footprint
a TCI levels of 11 non-placental tissues in HCC patients versus healthy subjects. b Receiver operator characteristic (ROC) analysis for distinguishing HCC patients with high tumor burden using liver TCI and blood cell TCI ratio, liver TCI, blood cell TCI, liver OCF, motif diversity score (MDS), and proportion of short cfDNA fragments (< 150 bp). c ROC analysis for distinguishing all HCC patients using the same six biomarkers as in (b). d TCI level of 11 non-placental tissues in cancer patients and healthy subjects from Cristiano et al.’s study. ns: p ≥ 0.05, **: p < 0.01, ****: p < 0.0001.
