Fig. 6: Viral, bacterial super-infection disrupts coordinated adaptive immune activation in the lung. | Communications Biology

Fig. 6: Viral, bacterial super-infection disrupts coordinated adaptive immune activation in the lung.

From: Influenza virus and Staphylococcus aureus super-infection disrupts spatially coordinated cellular immunity in the mouse lung

Fig. 6

A Spatial correlation between CD4+ T cells and B cells in inflammatory regions in samples infected with the influenza virus or infected with both the influenza virus and S. aureus. The score was derived from marker genes for CD4+ T cells and B cells (See Methods). P values generated by linear regression. B Spatial correlation between the score for CD4+ T cells and dendritic cells in inflammatory regions in samples infected with the influenza virus or infected with both influenza virus and S. aureus. C The proportion of CD4+ T cells and B cells in spots in inflammatory regions. D The strength of the signal ICOS-ICOSL in the inflammatory regions. The size of the dot indicates the proportion of spots with non-zero signal strength. The color of the dot indicates the average signal strength in spots in one sample. E The expression of Th17-related genes (Rorc, Il17a, Ccr6, Il22, Il17f) and Th1-related genes (Ccl5, Ms4a4b, Cxcr3, Ifng, Tbx21, Gzmk) in regions near airways for each sample.

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