Fig. 4: Differential cell-cell communication patterns between AC and SCC using CellChat on scRNA-seq data. | Communications Biology

Fig. 4: Differential cell-cell communication patterns between AC and SCC using CellChat on scRNA-seq data.

From: Single-cell and spatial transcriptomic profiling reveals distinct tumor microenvironment dynamics in cervical adenocarcinoma and squamous cell carcinoma

Fig. 4

a Comparative heatmap illustrating the most divergent cell-cell interactions involving pDCs, Tregs, S100A9+ and MKI67+ epithelial/tumor cells-both with themselves and with other cell populations- between AC and SCC. b Network graph of cell communication analysis of six cell subtypes (pDC, Treg, activated CD8 T/NK, CD8 T cells, MKI67+ and S100A9+ epithelial cells) in AC and SCC tumors. Comparison of putative ligand-receptor pairs involving interactions between CD8 + T cells or activated CD8 + T/NK cells and Tregs (c), pDCs (d), S100A9+ epithelial cells (e), and MKI67+ epithelial cells (f) in AC and SCC.

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