Fig. 6: Comparative analysis of microenvironmental cell-type abundance associated with specific target cell identities between AC and SCC. | Communications Biology

Fig. 6: Comparative analysis of microenvironmental cell-type abundance associated with specific target cell identities between AC and SCC.

From: Single-cell and spatial transcriptomic profiling reveals distinct tumor microenvironment dynamics in cervical adenocarcinoma and squamous cell carcinoma

Fig. 6

a Schematic illustration of quantified analysis on the abundance of surrounding cell types within specific area: for each target cell type, the spatial abundance of surrounding cell types was quantified within a 100-μm radial neighborhood of individual cells across all samples, followed by statistical analysis; scale bar is 50 mm. The boxplots showing cell types with statistically significant proportional difference (divided by 100-μm radial surrounding cell numbers) between AC and SCC samples surrounding pDC (b), Treg (d), MKI67+ epithelial cells (f) and S100A9+ epithelial cells (h). Representative images showing differential cell-type abundance around one target cell in AC and SCC samples, with the target cells pDC (c), Treg (e), MKI67+ epithelial cells (g) and S100A9+ epithelial cells (i).

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