Table 6 Duplications with high impact on genes that may be involved in insecticide resistance
From: Genome-wide analysis of genetic diversity in Anopheles darlingi from Rondônia State, Brazil
Chr | Duplication ID | Genes with HIGH impact as defined using SnpEff90 and the effect on these genes. | Frequency in wild-caught Rondônia State mosquitoes (%) | Frequency in colony mosquitoes (%) |
|---|---|---|---|---|
X | DUP00004667 | Frameshift and splice region variant in the cytochrome P450 4c3-like gene (LOC125953818) | 14.7 | 0 |
2 | DUP00010794 | Gene fusion involving two cytochrome p450 4d2-like genes (LOC125950881 and LOC125950889. Duplication between 14392190 and 14395703 (~3.5 kb). | 26.3 | 12.5 |
2 | DUP00010862 | Introduction of a premature stop codon and impacting a splice region in cytochrome P450 4d2-like gene (LOC1259483340) | 36.1 | 12.5 |
2 | DUP00019559 | Gene fusion between the cytochrome P450 4C1-like gene (LOC125950286) and the transmembrane and coiled-coil domain 2 protein (LOC125950273). Duplication between positions 36277503 and 36280083 (~2.5 kb). | 0 | 31.3 |
2 | DUP00019560 | Gene fusion between transmembrane and coiled-coil domain 2 protein (LOC125950273) and the cytochrome P450 4C1-like gene (LOC125950286). Gene fusion between LOC125950273 and the cytochrome P450 4C1-like gene (LOC125950311). Duplication between positions 36278078 and 36281104dup, ~3 kb. | 52.5 | 50.0 |
2 | DUP00019562 | Gene fusion between transmembrane and coiled-coil domain 2 protein (LOC125950273) and the cytochrome P450 4C1-like gene (LOC125950286). Gene fusion between LOC125950273 and the cytochrome P450 4C1-like gene (LOC125950311). Duplication between positions 36278947 and 36282009dup, ~3.1 kb). | 31.6 | 18.8 |
2 | DUP00044715 | Gene fusion between multidrug resistance-associated protein 1-like gene (LOC125951334) and ras-related protein Rab-9B (LOC125951567). Duplication of part of the glutathione S-transferase-1 like gene (LOC125951365). | 2.5 | 0 |
2 | DUP00048534 | Gene fusion between cytochrome P450 9f2s (LOC125952882 and LOC125952880). Duplication between positions 91682639 and 91685220, ~2.5 kb. | 2.78 | 43.75 |
3 | DUP00052410 | Gene fusion between two probable cytochrome P450 6a13 genes, LOC125956304 and LOC125958131. Duplication between positions 5372527 and 5375351 (~2.8 kb). | 17.65 | 6.25 |
3 | DUP00072025 | Gene fusion between probable cytochrome P450 313a4 (LOC125955537) and probable cytochrome P450 313a1 (LOC125955540) Duplication between positions 46108971 and 46118421 (~9.4 kb). | 41.7 | 43.8 |
3 | DUP00072031 | Duplication of cytochrome P450 3A19-like (LOC125955539), and a frameshift variant of this gene. Gene fusion between cytochrome P450 3A19-like (LOC125955539), probable cytochrome P450 313a4 (LOC125955538), probable cytochrome P450 313a4 (LOC125955537), and probable cytochrome P450 313a1 (LOC125955540) | 13.9 | 25.0 |
3 | DUP00075794 | Gene fusion between glutamate receptor 1-like (LOC125954300) and an uncharacterized protein (LOC125954378). Duplication between positions 52862921 and 53509817, ~647 kb. | 2.5 | 0 |
