Fig. 5: CSI selectivity and mismatch-related responses across CA1 and DG.
From: Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats
A Left panels display scatter plots of the frequency-specific SSA index (SI) for f1 (x-axis) vs. f2 (y-axis) in CA1 (top; n = 63; 6 rats) and DG (bottom; n = 107; 5 rats). Lighter shades denote non-CSI units (auditory-responsive after excluding CSI-significant), while CSI-significant units appear in a darker tone. Units in the top right quadrant show higher response to the deviant for both frequencies. Right panels show histograms of the common SSA Index (CSI) for CA1 (top) and DG (bottom). Red vertical lines represent the mean of the distribution. B Left panels show the distributions of the index of neuronal mismatch (iMM) for CA1 (top; n = 126; 6 rats) and DG (bottom; n = 214; 5 rats), with lighter colors representing non-CSI-significant units (auditory-responsive after excluding CSI-significant) and darker colors indicating CSI-significant units. Middle panels display the index of prediction error (iPE) and right panels the index of repetition suppression (iRS). These results show that prediction error is the main contributor to neuronal mismatch both in CA1 and DG. Red vertical lines mark each distribution’s median: the dashed line is the median of non-CSI-significant units, while the solid line indicates the median of CSI-significant units. Asterisks indicate that the median differs from zero according to a two-sided sign test with Bonferroni correction; *p < 0.05, **p < 0.01, ***p < 0.001. The underlying data for this Figure can be found in Supplementary Data 3.
