Fig. 4: Design and application of the microfluidic chip. | Communications Biology

Fig. 4: Design and application of the microfluidic chip.

From: Microgravity-cultured glioblastoma organoids integrated with microfluidic chip for CAR-γδ T evaluation

Fig. 4: Design and application of the microfluidic chip.

A Schematic diagram and workflow for co-culture of CAR-T cells and GBOs on the microfluidic chip. B Illustration of the microfluidic chip-based co-culture system. C COMSOL simulations of the microfluidic chip under static and dynamic flow conditions. D Effect and quantification of static versus dynamic culture conditions on the viability of GBOs and γδ T cells (n = 3). E Real-time interactions between B7-H3 CAR-γδ T cells and GBOs within the microfluidic chip. Error bars represent standard deviation (SD) of three biological replicates.

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